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  1. Emollients Reduce surface tension of the oil- water interface of the stool resulting in enhanced incorporation of water and fat, allowing for stool softening Docusate Colace, mineral oil Fleet mineral oil enema, various Mineral oil decreases absorption of vitamins and many drugs Osmolar agents Produce an osmotic effect in the colon with resultant distention promoting peristalsis Glycerin Fleet glycerin suppositories, magnesium citrate Citroma, magnesium sulfate various, lactulose Enulose, Generlac, polyethylene glycol MiraLax Nausea, bloating, cramping, rectal irritation; magnesium toxicity in renally impaired patients Stimulants Stimulate peristalsis by directly irritating the smooth muscle of the intestine Bisacodyl Dulcolax, senna Senokot Gastric irritation, fluid and electrolyte abnormalities Lubiprostone Bicyclic fatty acid that acts locally at the apical portion of the intestine as a chloride channel activator, increasing intestinal water secretion Lubiprostone Amitiza Headache, nausea, diarrhea. doxycycline for syphilis

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